ketoconazole 2% 와 zinc pyrithione 1% 어떤것이 더 효과적일까?

by hyewonmc posted Dec 29, 2011
ketoconazole 2% 와 zinc pyrithione 1% 어떤것이 더 효과적일까?

ketoconazole 2% 와 zinc pyrithione 1% 은 지루성피부염에 흔히 사용되는 약물입니다.
이 2가지 종류에서는 ketoconazole 2%가 더 치료에 효과적이라고 합니다.


 케토코나졸.png
ketoconazole




  징크 피리치온.gif
zinc pyrithione

이에 대한 실험 논문이 있습니다.
벨기에에서 발표한 논문입니다.

A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis.

Department of Dermatopathology, University Medical Center Sart Tilman, B-4000 Liege, Belgium.

Ketoconazole (KET) and zinc pyrithione (ZPT) are compounds active against the Malassezia spp. yeasts, which are believed to play a major role in dandruff and seborrheic dermatitis. We compared the efficacy and safety of KET 2% and ZPT 1% in shampoo formulations for the alleviation of severe dandruff and seborrheic dermatitis. This open randomized, parallel-group trial began with a 2-week run-in phase during which subjects applied a neutral non-antidandruff shampoo. It was followed by a 4-week randomized treatment phase and a subsequent 4-week follow-up phase without treatment. Shampooing during the treatment period was carried out twice weekly for the KET group and at least twice weekly for the ZPT group in accordance with the label instructions. A total of 343 subjects were recruited to enter the trial. Of the 331 eligible volunteers, 171 were randomized to KET 2% and 160 to ZPT 1%. Clinical assessments were performed. Beneficial effects were evidenced for both medicated shampoos, but the effect was significantly better for KET 2%, which achieved a 73% improvement in the total dandruff severity score compared with 67% for ZPT 1% at week 4 (p < 0.02). The recurrence rate of the disease was also significantly lower following KET 2% treatment than following ZPT 1% treatment. As a consequence, the overall clearing of the skin condition at the end of treatment and follow-up phase was in favor of the KET 2% formulation (p = 0.004). Side effects were minimal. It is concluded that after a 4-week treatment, KET 2% shampoo was significantly superior to ZPT 1% shampoo in the treatment of subjects with severe dandruff or seborrheic dermatitis of the scalp. It is our assumption that this difference is noticeable for the patient and as a consequence relevant. Both formulations were well tolerated.
Copyright 2002 S. Karger AG, Basel

이 논문의 색칠된 결론을 번역하면

.......(중략).  4주간의 치료후에  Ketoconazole (KET) 2% 샴푸가 zinc pyrithione (ZPT) 1% 샴푸보다 두피의 지루성피부염과 심한 비듬의 치료에서 유의성있게 우수한것으로 나타났다. 그래서 우리는 이 차이가 환자가 인식할 수 있는 정도이고, 결과도 그에 맞게 (우수하게) 나타는것으로  결론내렸다. .........

어떤 성분의 샴푸를 사용할 것인가 고민할 때 참고로 하세요.

 


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